Table 6. Chemical Structures and Antibacterial Activity of Compounds 10a–l.
| MIC
values (MBC values) μmol/mL ×
102 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| compd | R | B. cereus | M. flavus | S. aureus | L. monocytogenes | E. coli | E. cloacae | P. aeruginosa | S. typhimurium |
| 10a | H | 1.49 (2.97) | 2.97 (5.94) | 1.19 (1.49) | 1.49 (2.97) | 0.23 (2.97) | 1.49 (2.97) | 4.45 (5.94) | 1.49 (2.97) |
| 10b | 4-OH | 4.90 (9.80) | 9.80 (19.6) | 4.90 (9.80) | 4.90 (9.8) | 9.80 (19.6) | 4.90 (9.80) | 4.90 (9.80) | 4.90 (9.80) |
| 10c | 4-OCH3 | 4.80 (19.2) | 9.60 (19.2) | 4.80 (9.60) | 9.60 (19.2) | 14.4 (19.2) | 7.20 (9.60) | 9.60 (19.2) | 4.80 (9.60) |
| 10d | 4-OH; 3-OCH3 | 4.60 (9.20) | 13.9 (18.6) | 9.20 (37.3) | 18.6 (37.3) | 13.9 (18.6) | 6.90 (9.20) | 9.20 (37.3) | 3.45 (4.60) |
| 10e | 2-Cl | 4.80 (9.60) | 9.60 (19.2) | 4.80 (9.60) | 9.60 (19.2) | 9.60 (19.2) | 4.80 (9.60) | 9.60 (19.2) | 4.80 (9.60) |
| 10f | 3-Cl | 4.60 (9.20) | 4.60 (9.20) | 4.60 (9.20) | 4.60 (9.20) | 0.18 (0.36) | 4.60 (9.20) | 4.60 (9.20) | 4.60 (9.20) |
| 10g | 4-Cl | 4.80 (19.2) | 9.60 (19.2) | 4.80 (9.60) | 9.60 (19.2) | 9.60 (19.2) | 4.80 (9.60) | 9.60 (19.2) | 2.40 (4.80) |
| 10h | 2-NO2 | 9.10 (18.2) | 9.10 (18.2) | 9.10 (18.2) | 4.50 (9.10) | 9.10 (18.2) | 4.50 (9.10) | 4.50 (9.10) | 9.10 (18.2) |
| 10i | 3-NO2 | 14.0 (18.4) | 18.4 (36.8) | 14.0 (18.4) | 18.4 (36.8) | 23.3 (36.8) | 23.3 (36.8) | 18.4 (36.8) | 4.60 (9.20) |
| 10j | 4-NO2 | 0.58 (1.16) | 9.20 (18.4) | 0.58 (1.16) | 9.20 (18.4) | 9.20 (18.4) | 2.30 (9.20) | 9.20 (18.4) | 0.58 (1.16) |
| 10k | 4-OH; 3,5-OCH3 | 8.80 (17.6) | 8.80 (17.6) | 4.40 (8.80) | 2.20 (8.80) | 8.80 (17.6) | 4.40 (8.80) | 2.20 (8.80) | 2.20 (8.80) |
| 10l | 4-OH; 3-OCH3; 5-I | 7.20 (28.8) | 7.20 (14.4) | 3.60 (7.20) | 28.8 (36.0) | 7.20 (14.4) | 3.60 (14.4) | 14.4 (28.8) | 7.20 (14.4) |