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. 2021 Feb 16;299(1):97–106. doi: 10.1148/radiol.2021203179

Figure 4:

Bar chart of P values for radiomic features affected by cocaine use or elevated atherosclerotic cardiovascular disease (ASCVD) risk stratified by disease subgroups. A, Corresponding P values for cocaine use among the total population, elevated ASCVD risk, and low ASCVD risk subgroups, shown in different shades of blue. B, Corresponding P values for ASCVD risk among the total population and among cocaine user and nonuser subgroups, shown in different shades of green. Bars above the red line (P = .00004) indicate significant associations. Results indicate that modifying effects of cocaine use may require a susceptible environment (increased ASCVD risk) to occur. However, once it is present, it modifies the morphologic features of atherosclerosis differently than ASCVD risk. In addition, ASCVD risk may have a more profound effect among cocaine nonusers, which may imply that the effects of cocaine use on morphologic changes overwhelm the effects of ASCVD.

Bar chart of P values for radiomic features affected by cocaine use or elevated atherosclerotic cardiovascular disease (ASCVD) risk stratified by disease subgroups. A, Corresponding P values for cocaine use among the total population, elevated ASCVD risk, and low ASCVD risk subgroups, shown in different shades of blue. B, Corresponding P values for ASCVD risk among the total population and among cocaine user and nonuser subgroups, shown in different shades of green. Bars above the red line (P = .00004) indicate significant associations. Results indicate that modifying effects of cocaine use may require a susceptible environment (increased ASCVD risk) to occur. However, once it is present, it modifies the morphologic features of atherosclerosis differently than ASCVD risk. In addition, ASCVD risk may have a more profound effect among cocaine nonusers, which may imply that the effects of cocaine use on morphologic changes overwhelm the effects of ASCVD.