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| compound | EC50 |
|---|---|
| 1 | >25 μM |
| 10 | >25 μM |
| 18 | 15.7 μM |
| 19 | >25 μM |
| 2 | 10.5 μM |
| 21 | 14.7 μM |
| 20 | 4.9 μM |
| 22 | 23.1 μM |
PPAR-γ modulation activity of the phytocannabinoids 1, 10, 18, and 19 and their corresponding cannabinoquinones (2, 21, 20, and 22). Rosiglitazone (1 μM) was used as positive control for PPAR-γ activation (50-fold induction over basal activity).
