Table 1. Results of deconvolution of bisulfite sequencing data from reference tissues for scenarios of (A) pregnancy, (B) lung transplantation, and (C) liver cancer.
The underlinedĀ numbers represent the percentage of contribution accurately assigned to the respective tissues by genetic-epigenetic tissue mapping (GETMap).
(A) | Tissue contribution as determined by GETMap analysis | |||||
---|---|---|---|---|---|---|
Neutrophils | Lymphocytes | Liver | Lung | Placenta | ||
Reference tissue used for the simulation | Neutrophils | 96.78 | 2.01 | 0.59 | 0.33 | 0.29 |
Lymphocytes | 0.52 | 98.30 | 0.41 | 0.20 | 0.58 | |
Liver | 0.31 | 0.64 | 98.36 | 0.27 | 0.42 | |
Lung | 0.24 | 0.66 | 0.35 | 98.36 | 0.39 | |
Placenta | 0.13 | 0.05 | 0.00 | 0.09 | 99.73 | |
(B) | Tissue contribution as determined by GETMap analysis | |||||
Neutrophils | Lymphocytes | Liver | Lung | Placenta | ||
Reference tissue used for the simulation | Neutrophils | 98.21 | 0.77 | 0.42 | 0.43 | 0.17 |
Lymphocytes | 0.48 | 98.70 | 0.20 | 0.31 | 0.31 | |
Liver | 0.32 | 0.19 | 99.25 | 0.11 | 0.13 | |
Lung | 0.21 | 0.09 | 0.22 | 99.39 | 0.09 | |
Placenta | 0.00 | 0.09 | 0.08 | 0.05 | 99.78 | |
(C) | Tissue contribution as determined by GETMap analysis | |||||
Neutrophils | Lymphocytes | Liver | Lung | Placenta | ||
Reference tissue used for the simulation | Neutrophils | 96.08 | 2.23 | 0.32 | 0.37 | 1.00 |
Lymphocytes | 0.94 | 95.46 | 0.79 | 2.06 | 0.75 | |
Liver | 0.50 | 0.44 | 96.67 | 1.48 | 0.91 | |
Lung | 0.90 | 1.71 | 0.80 | 96.08 | 0.51 | |
Placenta | 0.49 | 0.13 | 0.77 | 0.34 | 98.27 |