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. 2021 Mar 26;168:105581. doi: 10.1016/j.phrs.2021.105581

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Fig. 1 — The scheme recapitulates the sequence of SARS-CoV-2 infectious disease evolution from high-risk subjects exposed to psychosocial stress towards patients with severe COVID-19 (A); (B) main features of heart-brain axis dysfunction in humans with interstitial pneumonia induced by SARS-CoV-2 following its vascular and transneuronal spreading. BDNF, brain-derived neurotrophic factor; HBA, heart-brain axis; IL, interleukin; MODS, multiorgan disease syndrome; ROS, radical oxygen species.