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. 2021 Mar 25;31(2):172–181. doi: 10.1089/nat.2020.0907

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© Yuichiro Tone, et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — Multiexon skipping using the three-PPMO-based cocktail in immortalized myoblast lines. (a) RT-PCR of immortalized CXMD_J clone 9 treated with PMO or PPMO. Exon 6 to 9 skipping efficiency for each PMO and PPMO compound is depicted as a bar graph and EC₅₀ values are noted on the right-hand site. Exon skipping efficiency is represented as the mean ± standard deviation. N = 3; ***P < 0.001. NT, not treated. (b) Western blotting analysis for dystrophin expression. M, high-molecular-weight protein marker. EC₅₀, effective concentration; PPMO, Pip8b2-conjugated PMO.