Table 2.
For the 141 identified candidate loci, related genes were found by proximity, cis or trans eQTLs, or by gene prioritization in DEPICT.
| Locus | SNPs | p | Genes |
|---|---|---|---|
| 1 | rs983098(*), rs1374038, rs10461655 | 0.00004 | PARP8(d) |
| 2 | rs1352436(*) | 0.00004 | ENSG00000250546(d) |
| 3 | rs12692720(*), rs6432774, rs1528431, rs6743187 | 0.00004 | RND3(n,d), LINC01920(d) |
| 4 | rs199635(*), rs852937, rs543827, rs473757, rs6918162 | 0.00004 | LINC01626(n), LINC00472(d), OGFRL1(ce) |
| 5 | rs34814294(*) | 0.00004 | MMP28(n*,d), CCL5(d), HEATR9(d), RDM1(d), TAF15(d), LYZL6(d) |
| 6 | rs3849324(*) | 0.00008 | MALL(n*,d), LINC00116(d), NPHP1(d) |
| 7 | rs6538046(*), rs10858436, rs4503615, rs2406250, rs2406254 | 0.00008 | MGAT4C(n*,d) |
| 8 | rs4755718(*), rs7929359, rs12273774, rs4755689, rs7929102, rs10768008, rs7939586 | 0.00008 | KIAA1549L(n*,d), ENSG00000255207(d) |
| 9 | rs11874286(*), rs1025206, rs16970618, rs12457667, rs8093155 | 0.00008 | LOC105372076(n#), MIR924HG(d) |
| 10 | rs6687976(*), | 0.00012 | LINC01676(d) |
| 11 | rs2123269(*), rs2100346, rs6987013 | 0.00012 | MRPS28(n*,d), TPD52(d,ce) |
| 12 | rs7744306(*), rs9347666, rs9456798, rs10945861 | 0.00012 | PACRG(n*,d), PARK2(n,d) |
| 13 | rs10950657(*), rs6968554, rs1476080 | 0.00012 | AHR(n,d), LOC101927609(n#), ENSG00000237773(d#), ENSG00000236318(d#) |
| 14 | rs9459964(*) | 0.00016 | LOC105378150(n*#), ENSG00000232197(d#) |
| 15 | rs4466027(*), rs7673254, rs13121254 | 0.00016 | LINC02261(n*), STIM2(d) |
| 16 | rs6988639(*), rs1433393, rs2656118 | 0.00016 | SNTB1(d), HAS2(d) |
| 17 | rs12439991(*), rs7163517, rs11857756 | 0.00016 | LOC105370777(n*), ENSG00000259450(d) |
| 18 | rs10932020(*), rs7591187 | 0.00016 | CD28(d,ce) |
| 19 | rs6813846(*), rs9997501, rs892836 | 0.0002 | STOX2(n*,d) |
| 20 | rs7748814(*), rs7742883, rs6914805, rs6459467 | 0.0002 | GMPR(d,ce), ATXN1(d,ce) |
| 21 | rs2331545(*) | 0.0002 | OVAAL(n*,d) |
| 22 | rs676740(*) | 0.0002 | AFDN(n*,d), ENSG00000235994(d) |
| 23 | rs1263635(*), rs943888 | 0.00024 | TRAC(d) |
| 24 | rs755535(*), rs12108497, rs2130392, rs4069938 | 0.00024 | PRIMPOL(n,d,ce), CENPU(n,d,ce), ACSL1(n), CASP3(d,ce) |
| 25 | rs11164896(*), rs2783499 | 0.00024 | CCDC18(n,d,ce), DR1(d,ce), TMED5(d,ce), MTF2(d), FNBP1L(d), CCDC18-AS1(d) |
| 26 | rs9324446(*), rs3887806, rs7837472 | 0.00024 | FAM135B(d) |
| 27 | rs3934720(*) | 0.00024 | EIF2B5(d) |
| 28 | rs7702793(*) | 0.00024 | LOC105379160(n*#), GRAMD3(d) |
| 29 | rs10034996(*) | 0.00024 | ENSG00000251199(d) |
| 30 | rs1826613(*), rs1227842 | 0.00024 | DLG2(n*,d) |
| 31 | rs4757245(*), rs4756786, rs2970335, rs11023194, rs11023197, rs6486191, rs11023210, rs3923294, rs12295888, rs11023223, rs2575825, rs10832275 | 0.00028 | SPON1(n,d), PDE3B(d), RRAS2(d), COPB1(d,ce) |
| 32 | rs1387092(*), rs1488745, rs6802020 | 0.00028 | CNTN4(d) |
| 33 | rs17790008(*), rs6584652 | 0.00032 | SORCS3(n*,d) |
| 34 | rs10828065(*), rs12355916 | 0.00032 | PLXDC2(d) |
| 35 | rs596557(*) | 0.00032 | TMX3(d) |
| 36 | rs17377955(*) | 0.00032 | DGKB(d) |
| 37 | rs11582429(*), rs2168951 | 0.00032 | LINC01732(d) |
| 38 | rs9949956(*), rs8095771, rs12966370, rs7236288, rs10871565 | 0.00032 | LINC01029(n), GALR1(d) |
| 39 | rs6816525(*) | 0.00032 | IRF2(n*,d) |
| 40 | rs4896501(*), rs7753475 | 0.00032 | CLVS2(d) |
| 41 | rs2554728(*) | 0.00032 | CSMD1(n*,d) |
| 42 | rs10503759(*), rs969456 | 0.00032 | LOC101929294(n*#), ADAM7(d), ENSG00000253643(d#), ADAMDEC1(ce) |
| 43 | rs4858795(*), rs6794875 | 0.00032 | SHISA5(n*,d), PLXNB1(n,d), CCDC51(d), FBXW12(d), PFKFB4(d,ce), TREX1(ce), ATRIP(ce), NME6(ce), NCKIPSD(ce) |
| 44 | rs4662553(*) | 0.00036 | LRP1B(d) |
| 45 | rs17756443(*), rs16959991 | 0.00036 | CDH13(n*,d) |
| 46 | rs5931289(*), rs5929883, rs5931353 | 0.00036 | – |
| 47 | rs12920637(*), rs7198542 | 0.00036 | CDH13(n*,d) |
| 48 | rs7745485(*), rs12524966, rs12198618 | 0.00036 | LOC105374974(n#), HDGFL1(d) |
| 49 | rs6692(*), rs9555784 | 0.0004 | ARHGEF7(n*,d,ce) |
| 50 | rs6467607(*) | 0.0004 | SLC13A4(d) |
| 51 | rs10902531(*) | 0.0004 | SFSWAP(d) |
| 52 | rs2215375(*) | 0.0004 | SPP2(d) |
| 53 | rs7101204(*) | 0.0004 | SVIL(n*,d) |
| 54 | rs1555145(*) | 0.0004 | BTBD3(d) |
| 55 | rs13243936(*) | 0.0004 | EPDR1(d), NME8(ce), GPR141(ce) |
| 56 | rs11772261(*), rs11770352, rs6462776, rs4723679, rs6462780 | 0.0004 | EPDR1(d) |
| 57 | rs4432837(*), rs6864394 | 0.0004 | RGS7BP(n*,d) |
| 58 | rs11736162(*), rs1439381, rs1439382, rs7684647 | 0.00044 | GUF1(d,ce), GNPDA2(ce) |
| 59 | rs9459963(*), rs9366130, rs4540249 | 0.00044 | ENSG00000232197(d), DLL1(ce), FAM120B(ce) |
| 60 | rs4676617(*) | 0.00044 | LOC102724104(n*#), CX3CR1(d,ce), WDR48(ce) |
| 61 | rs11025878(*), rs4644637, rs7941875 | 0.00044 | NELL1(n*,d) |
| 62 | rs2040664(*) | 0.00044 | DNAH11(n*,d) |
| 63 | rs11066610(*), rs16942882, rs11066638 | 0.00044 | LHX5(d), LINC01234(d) |
| 64 | rs1366906(*), rs6485532 | 0.00048 | CD82(d) |
| 65 | rs3866223(*), rs11241999 | 0.00048 | ADAMTS19(n*,d) |
| 66 | rs2275696(*), rs3892248 | 0.00048 | NFASC(n*,d), DSTYK(ce) |
| 67 | rs12688573(*), rs5936239, rs2341921, rs758439 | 0.00048 | AFF2(n*) |
| 68 | rs2027469(*) | 0.00048 | CRP(d), DUSP23(ce) |
| 69 | rs11800877(*), rs4657327, rs1415439, rs12076657 | 0.00048 | PBX1(d) |
| 70 | rs2070584(*) | 0.00052 | TIMP1(n*) |
| 71 | rs28890299(*) | 0.00052 | LIPI(n*) |
| 72 | rs11643432(*), rs10514583 | 0.00052 | CDH13(n*,d) |
| 73 | rs4237648(*), rs10742717, rs4237647, rs1665150 | 0.00052 | TSPAN18(n,d) |
| 74 | rs4689203(*), rs13123841, rs10937629, rs13121492 | 0.00056 | STK32B(n*,d) |
| 75 | rs9530423(*), rs1359500, rs9573531 | 0.00056 | TBC1D4(n*,d) |
| 76 | rs7143719(*), | 0.00056 | TSHR(n*,d) |
| 77 | rs10822863(*), rs2894011, rs2894015, rs4143863 | 0.00056 | CTNNA3(n*,d) |
| 78 | rs7610664(*), rs7609933 | 0.00056 | FGF12(n*,d) |
| 79 | rs6558831(*), rs12680491, rs11136689 | 0.00056 | CSMD1(n*,d) |
| 80 | rs4751878(*), rs4752666, rs10887101, rs6585804, rs11592039 | 0.00056 | TACC2(n*,d) |
| 81 | rs12965155(*) | 0.00056 | MIR924HG(d) |
| 82 | rs760150(*) | 0.00056 | PCP4(n*,d), TMPRSS3(d) |
| 83 | rs239953(*) | 0.00056 | POR(n*,d,ce), RHBDD2(d,ce) |
| 84 | rs10182928(*) | 0.00056 | SATB2(d), SATB2-AS1(d) |
| 85 | rs617459(*), rs657426 | 0.0006 | SETBP1(n*,d) |
| 86 | rs12165104(*), rs12954590 | 0.0006 | TNFRSF11A(n*,d), ZCCHC2(d) |
| 87 | rs11688528(*) | 0.00064 | LOC100506474(n*#), TRIB2(d) |
| 88 | rs6966799(*) | 0.00064 | HDAC9(d) |
| 89 | rs6759648(*), rs7593846, rs9941639 | 0.00064 | LINC01798(n*), MEIS1(d) |
| 90 | rs2973419(*) | 0.00064 | PRR16(d) |
| 91 | rs10456118(*), rs10948172, rs857601, rs3799977, rs4714828, rs10948197, rs6919813 | 0.00064 | SUPT3H(n,d,ce), RUNX2(d) |
| 92 | rs4795934(*), rs990510, rs12944367 | 0.00064 | TMEM132E(d) |
| 93 | rs7831168(*), rs13269649, rs907991 | 0.00068 | FAM135B(d) |
| 94 | rs9880546(*) | 0.00068 | LINC00578(n*), TBL1XR1(d) |
| 95 | rs1375547(*), rs9861237, rs9822731, rs12498010, rs9880919 | 0.00068 | CADM2(n*,d) |
| 96 | rs6557678(*), rs6988938, rs7824718, rs7009973, rs7008867 | 0.00068 | SLC25A37(d,ce), ENTPD4(ce), AC051642.5(ce#) |
| 97 | rs16993897(*) | 0.00068 | VAV1(d), ADGRE1(ce) |
| 98 | rs16999330(*), rs4434196 | 0.00068 | FSTL5(n*,d) |
| 99 | rs16880318(*), rs16880352 | 0.00072 | KCNV1(d) |
| 100 | rs4947522(*), rs28633916, rs9642409 | 0.00072 | COBL(d) |
| 101 | rs17078840(*) | 0.00072 | LINC00327(d) |
| 102 | rs40566(*) | 0.00072 | C5orf67(n*), MAP3K1(d) |
| 103 | rs4528743(*) | 0.00072 | SLC16A14(n*,d) |
| 104 | rs13249135(*) | 0.00072 | MIR2052HG(n*,d) |
| 105 | rs747925(*), rs11236683 | 0.00072 | LOC105369395(n*#), THAP12(d) |
| 106 | rs10505371(*), rs17803964 | 0.00076 | ENPP2(n*,d), TAF2(ce) |
| 107 | rs3911618(*) | 0.00076 | RGS7(n*,d) |
| 108 | rs7691972(*) | 0.00076 | ACSL1(n*,d), CASP3(ce) |
| 109 | rs6507498(*), rs9807753, rs8093542 | 0.00076 | CABLES1(d) |
| 110 | rs7722584(*), rs11948927 | 0.00076 | NLN(d) |
| 111 | rs3812278(*), rs10255837 | 0.00076 | CNOT4(n*,d), NUP205(d) |
| 112 | rs6773957(*), rs6444175 | 0.0008 | ADIPOQ(n*,d), LYST(te) |
| 113 | rs10858680(*), rs10777082, rs11104704, rs11104713 | 0.0008 | C12orf50(n*,d) |
| 114 | rs4577099(*) | 0.0008 | LOC102724084(n*#), DYNLRB2(d) |
| 115 | rs8030490(*) | 0.0008 | AKAP13(n*,d,ce) |
| 116 | rs11610234(*), rs4334084 | 0.0008 | TMEM132B(n*,d) |
| 117 | rs4762060(*) | 0.0008 | KRT80(n*,d), C12orf80(d) |
| 118 | rs6673313(*) | 0.0008 | LOC105378764(n*#), NFIA(d) |
| 119 | rs2506145(*) | 0.00084 | NRP1(n*,d) |
| 120 | rs898918(*), rs12100703 | 0.00084 | LINC01550(d) |
| 121 | rs4607409(*), rs300121, rs777573, rs9356411, rs9348092 | 0.00084 | LINC00473(n,d), LOC105378117(n#), T(d), MPC1(ce) |
| 122 | rs2147866(*), rs6891675 | 0.00084 | CCDC192(n*), LINC01184(d) |
| 123 | rs8178838(*) | 0.00088 | APOH(n*,d), CEP112(d) |
| 124 | rs13406850(*), rs10172452, rs1628975 | 0.00088 | LRP1B(d) |
| 125 | rs745247(*), rs7739748 | 0.00092 | CD83(d) |
| 126 | rs6934819(*) | 0.00092 | ENPP3(d) |
| 127 | rs7916162(*) | 0.00092 | TACC2(n*,d), PLEKHA1(ce) |
| 128 | rs10764344(*), rs11013053 | 0.00092 | PIP4K2A(n*,d), PIP5K2A(ce) |
| 129 | rs3003177(*) | 0.00092 | ENSG00000223786(d#) |
| 130 | rs949719(*), rs1516651 | 0.00092 | ATP10B(n*,d) |
| 131 | rs938025(*) | 0.00096 | LINC00616(d), SLC7A11-AS1(d) |
| 132 | rs11640395(*) | 0.00096 | ZFHX3(n*,d) |
| 133 | rs2201369(*), rs10481102, rs13439041 | 0.00096 | BAALC(n*,d), BAALC-AS2(d) |
| 134 | rs4521178(*) | 0.00096 | CPB1(n*,d), CPA3(d,ce) |
| 135 | rs1400438(*), rs1516893 | 0.00096 | LINC01505(d) |
| 136 | rs9864293(*) | 0.00096 | IL1RAP(d) |
| 137 | rs2236570(*), rs613089 | 0.00096 | BCL9(n*,d,ce), ACP6(d) |
| 138 | rs10868152(*), rs7022329 | 0.00096 | SLC28A3(n*,d) |
| 139 | rs10501827(*) | 0.001 | SESN3(d) |
| 140 | rs8064765(*), rs11656652, rs11079045, rs1032070, rs8069972, rs2292755, rs4792992, rs4793253, rs7224577 | 0.001 | ATP6V0A1(n,d), CAVIN1(n,d), LOC102725238(n#), EZH1(d), CCR10(d), PLEKHH3(d), RETREG3(n,d), MLX(n,d), TUBG1(d), COASY(d,ce), CNTNAP1(d), TUBG2(d), HSD17B1(d), NAGLU(d), PSMC3IP(d), STAT3(ce), BECN1(ce) |
| 141 | rs12750904(*) | 0.001 | ABCD3(n*,d,ce), F3(d) |
Loci are ranked by p, which is the empirical p for association of the index SNP with cardiovascular events. Reference SNP cluster IDs are reported for the index SNP (marked with an asterisk) and non-index clumped SNPs in the locus. For all SNPs in the locus, relevant genes were identified by proximity to the index or non-index SNPs (annotated with n in parenthesis, with an asterisk denoting genes in proximity to the index SNP). Additional relevant genes are reported based on cis and trans eQTLs (annotated with ce and te, respectively), and based on gene prioritization in DEPICT (annotated with d). Genes are reported by HGNC gene symbol if possible, or alternatively by Ensemble identifiers if no HGNC gene symbol exists.
DEPICT data-driven expression-prioritized integration for complex traits, eQTL expression quantitative trait loci, HGNC human genome organisation gene nomenclature committee, SNP single nucleotide polymorphism.