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. 2021 Mar 26;12(4):326. doi: 10.1038/s41419-021-03494-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — There were four groups of activated HSCs under different transfections: sh-NC, sh-MIRLET7BHG#1, sh-MIRLET7BHG#1+pcDNA3.1/NC, and sh-MIRLET7BHG#1+pcDNA3.1/SMO. A Western blot detected the protein level of α-SMA and FAP in different groups. B–C EdU and colony formation assays examined the proliferation of activated HSCs under different contexts. D–E Wound-healing and transwell assays analyzed cell migration and invasion capacity in different groups. F–G Western blot and sphere formation assays analyzed changes in EMT process and stemness of activated HSCs in face of indicated transfections. **P < 0.01.