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. 2021 Mar 26;7:60. doi: 10.1038/s41420-021-00424-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Immunoblot results indicated H₂O₂ treatment caused time and dosage-dependent decreases in neuronal BAG3. B qPCR demonstrated H₂O₂ treatment causes significant decreases in neuronal BAG3 RNA. C In addition to validating H₂O₂-induced reductions in BAG3 protein, immunocytochemistry suggested neurons exposed to H₂O₂ treatment may develop minor dystrophies in their branching processes. D Immunoblotting revealed H₂O₂ reduced other BAG family members (BAG2, BAG5, BAG6), and exacerbated the reduction in BAG3 observed in response to Tat or Nef. ***p < 0.001. Scale bar equals 50 μM; ×40 magnification. Scale bar equals 20 μM; ×63 magnification.