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. 2021 Mar 26;11:6996. doi: 10.1038/s41598-021-86489-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of CRP and CRP⁺ extracellular vesicles from plasma from sepsis patients. Plasma from sepsis patients (6 patients; n = 3 for each patient) was incubated with (+) or without (−) PentraSorb for 30 and 60 min to deplete CRP, as described in the Methods section. EV counts (a), CRP-carrying (CRP⁺) EVs (b), as well as plasma CRP (c) were quantified at baseline (0 min), and after 30 and 60 min. The decrease of plasma EV counts over time was mainly due to unspecific binding of EVs by the adsorbent, as a comparable drop in EV counts was observed for the non-functionalized adsorbent matrix (non-functionalized agarose), as shown in Supplementary Fig. S2. CRP⁺ EVs and plasma CRP were efficiently depleted by PentraSorb treatment. (d) Summary of data as mean of all six patients for EV counts, CRP⁺ EVs, as well as plasma CRP. Data are given as mean ± SD and were compared using a two-way ANOVA; *p < 0.05, **p < 0.01, ***p < 0.001.