Fig. 3. LXRα S196A promotes expression of genes regulating mitochondrial activity, decreases inflammatory pathways in plaque macrophages, and reprograms plaque T cell transcriptome.

A Number of genes regulated by LXRα S196A versus WT by RNA seq from plaque laser captured microdissected CD68⁺ cells (LogFC > 0.6, p-value < 0.05). B Enriched pathways in plaque CD68⁺ in S196A after differential gene expression (DGE) analysis using Ingenuity Pathway Analysis (IPA). C Transcriptional regulators associate with upregulated or downregulated genes in plaque CD68⁺ cells were determined by IPA transcription factor analysis. D Number of genes regulated by LXRα S196A versus WT by RNA seq from sorted T cells (LogFC > 1, FDR < 0.05). E Enriched pathways in plaque T cells in S196A after DGE analysis using IPA. F Transcriptional regulators controlling the upregulated or downregulated genes in plaque T cells. G Comparison of the differentially expressed genes in plaque CD68⁺ versus plaque T cells.