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. 2021 Mar 26;4:413. doi: 10.1038/s42003-021-01918-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Verticality for all prokaryotic gene families (light brown) and for LBCA gene families (dark brown) and Kolmogorov–Smirnov statistics between the two distributions. b LBCA metabolic network annotated with verticality value for each reaction node.