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. 2021 Mar 26;11:6980. doi: 10.1038/s41598-021-86465-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-seq simulation results. Area under the ROC curves (AUCs) of eight meta-analysis methods were compared for different numbers of associated studies and significant genes. Among 20 studies used for the meta-analysis, 2, 5 and 10 studies were introduced as associated studies. The results with 10, 30 and 60% of significant genes are shown in the first, second, and third rows, respectively.