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. 2021 Mar 26;4:416. doi: 10.1038/s42003-021-01940-6

Fig. 5. INPP4B regulates metabolic and PPAR pathways in mouse liver.

Fig. 5

a RNAs were extracted from livers of HFD WT (N = 4) and HFD Inpp4b−/− (N = 4) mice and submitted for RNA sequencing. The changes in gene expression were compared between HFD WT and HFD Inpp4b−/− mice. b KEGG pathway functional enrichment analysis was done using DAVID functional annotation module or GSEA. The vertical axis represents the KEGG pathway terms significantly enriched by the loss of INPP4B in mouse liver. The horizontal axis shows the logarithmic scale of the p value. c–i RNA from LFD WT (N = 10), LFD Inpp4b−/− (N = 12), HFD WT (N = 8), and HFD Inpp4b−/− (N = 10) mice were analyzed for Pparg (c), Cd36 (d), Mogat1 (e), Vldlr (f), Cyp2b9 (g), Cyp2b13 (h), and Hao2 (i) by qRT-PCR using 18S as an internal control. j Correlation between INPP4B expression and PPARG expression in 289 human liver samples (GSE24335) (**p < 0.01, ***p < 0.001, ****p < 0.0001. Exact p values are provided in the Source data).