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. 2021 Mar 26;11:6990. doi: 10.1038/s41598-021-86505-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Coronal view of ANCOVA analysis between HC and AD subjects for standard DTI metrics. Clusters are reported at a significance threshold of p-value < 0.01 corrected for FWE. (a) FA, (b) AxD, and (c) RD analysis. The color bars indicate values that are lower in AD than HC (red-to-yellow) and higher in AD than HC (blue-to-cyan). For axial and radial diffusivities, only clusters with higher values in AD than HC were found. The corresponding violin plots represent the DTI metrics inside the significant clusters for each group.