Table 2.
Brain locations where clusters of significant differences between groups were found for both standard and FW-DTI analyses.
| Standard DTI | Free-water DTI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| FA (HC) > FA (AD) | FA (HC) < FA (AD) | AD (HC) < AD (AD) | RD (HC) < RD (AD) | FA (HC) > FA (AD) | FA (HC) < FA (AD) | AD (HC) > AD (AD) | AD (HC) < AD (AD) | RD (HC) > RD (AD) | RD (HC) < RD (AD)* | |
| % | % | % | % | % | % | % | % | % | % | |
| JHU WM tract. atlas | ||||||||||
| Left ATR | – | – | 34.13 | 31.06 | – | 7.91 | 0.42 | 1.95 | 6.12 | – |
| Right ATR | – | 1.14 | 31.99 | 28.51 | – | 9.96 | 0.53 | 1.64 | 6.79 | – |
| Left CST | – | – | 12.67 | 10.72 | – | 3.96 | – | 2.92 | 5.11 | – |
| Right CST | – | 1.59 | 14.34 | 16.38 | – | 8.47 | – | 6.06 | 8.97 | – |
| Left CGC | 6.41 | – | 9.77 | 38.37 | 1.90 | – | 4.34 | – | – | – |
| Right CGC | – | – | 24.44 | 41.83 | – | – | 1.62 | – | – | – |
| CGH | – | – | 60.13 | 61.44 | – | – | – | – | 3.8 (only R) | – |
| Forceps major | – | – | 7.68 | 39.35 | – | – | – | – | – | – |
| Forceps minor | 7.76 | – | 18.98 | 33.10 | 4.78 | – | 5.60 | – | – | – |
| IFOF left ATR | – | – | 19.25 | 43.47 | – | – | 2.19 | – | 1.67 | – |
| ILF | – | – | 23.83 | 43.79 | – | – | 1.48 | – | 3.86 | – |
| SLF | – | – | 14.15 | 19.48 | – | – | – | – | – | – |
| UF | – | – | 30.18 | 48.35 | – | – | 0.61 | – | – | – |
| ICBM-DTI-81 WM atlas | ||||||||||
| Genu of CC | 44.91 | – | 39.39 | 88.39 | 30.35 | – | 34.10 | – | – | – |
| Body of CC | 57.12 | – | 11.17 | 70.68 | 31.19 | – | 13.59 | – | – | 1.21 |
| Splenium of CC | 9.73 | – | 33.36 | 58.75 | 1.45 | – | – | – | – | – |
| Fornix | 93.33 | – | 73.93 | 93.74 | 70.91 | – | 45.99 | – | – | – |
| Left SCP | – | – | – | 10.60 | – | – | – | – | – | – |
| CP | – | – | 25.01 | 59.53 | – | – | – | – | – | – |
| Anterior LIC | – | – | 30.96 | – | – | 29.10 | – | 2.63 | 12.43 | – |
| Right posterior LIC | – | 5.83 | 39.59 | – | – | 39.77 | – | 30.58 | 38.67 | – |
| Left posterior LIC | – | – | 23.00 | – | – | 26.97 | – | 4.17 | 32.23 | – |
| Retrolenticular part of IC | – | – | 23.24 | 27.28 | – | 10.26 | 16.94 | 7.12 | 12.96 | – |
| Right anterior CR | – | – | 18.73 | 29.55 | – | – | 1.47 | – | – | – |
| Left anterior CR | 8.88 | – | 26.05 | 42.95 | – | – | 2.96 | 1.26 | – | – |
| Right superior CR | – | 1.22 | 28.58 | – | – | 17.71 | – | 6.93 | 18.13 | – |
| Left superior CR | – | – | 20.72 | – | – | 9.08 | – | – | – | – |
| Right posterior CR | 5.30 | – | 29.71 | 16.34 | – | 7.08 | – | 3.69 | 11.16 | – |
| Left Posterior CR | – | – | 14.94 | – | – | – | – | 2.98 | – | – |
| Sagittal stratum | – | – | 50.70 | 82.00 | – | – | 8.15 | – | 16.92 (only R) | – |
| External capsule | – | – | 22.84 | 33.57 | – | 8.23 | – | – | – | – |
| Right CGC | – | – | 30.58 | 62.75 | – | – | – | – | – | – |
| Left CGC | 8.11 | – | 13.79 | 61.95 | – | – | 2.74 | – | – | – |
| Cingulum (hippocampus) | – | – | 85.22 | 86.79 | – | – | – | – | – | – |
| SFOF | – | – | 87.14 | – | – | 61.03 | – | 10.94 | 40.13 | – |
All results are shown for p < 0.01 (FWE corrected), except for the last column, indicated by *, where RD (HC) < RD (AD) is reported at p < 0.05 (FWE corrected). % columns indicate the percent volume of the cluster inside the corresponding brain area.
For JHU white-matter tractography atlas: ATR anterior thalamic radiation, CST cortical spinal tract, CGC cingulum (cingulate gyrus part), CGH cingulum (hippocampal part), IFOF inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, UF uncinate fasciculus. For ICBM-DTI-81 white-matter atlas: CC corpus callosum, LIC limb of internal capsule, IC internal capsule, CR corona radiate, SS sagittal stratum, SFOF superior fronto-occipital fasciculus.