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. 2021 Mar 26;4:421. doi: 10.1038/s42003-021-01900-0

Fig. 2. Vitamin B6-deficient dams have normal insulin secretion, but heightened insulin sensitivity during pregnancy.

Fig. 2

At GD 12.5, VB6D dams have normal fasting insulin levels and insulin secretion response when glucose challenged compared to controls (A). At GD 12.5, VB6D has decreased insulin sensitivity compared to control (B). At GD 16.5, VB6D dams have normal fasting insulin levels and insulin secretion response when glucose challenged compared to control (C). At GD16.5, VB6D dams are more insulin sensitive compared to control indicated by a more significant reduction in glucose compared to controls (D). Data represent 5–8 mice per treatment group. Analysis of all panels was done by a two-way, repeated-measures ANOVA. A main effect of diet was observed in panel (B). In panel D, we identified a diet × time interaction effect, and a post hoc Holm–Sidak’s test was subsequently conducted which revealed that the percent fasting glucose at T = 15 and 30 min were significantly different between the groups. *p ≤ 0.05.