Table 3.

R2 values of the zero-order, first-order kinetic, Higuchi models, Korsmeyer–Peppas and Weibull models. Kinetic parameters for the Korsmeyer–Peppas model: K represents the release rate constant; n represents the release mechanism of drug. Kinetic parameters for the Weibull model: a represents a constant based on the system, and b a constant based on the release kinetics.

Prodrug	Zero-Order	First-Order	Higuchi	Korsmeyer-Peppas	Weibull	K	n	a	b
DSPE-MTX	0.9796	0.9824	0.9004	0.9830	0.8905	6.80	0.9931	0.0527	1.3510
PEG-MTX	0.9648	0.9847	0.9821	0.9931	0.9672	13.85	0.64	0.1353	0.8829
DSPE-MTX_ PEG-MTX	0.9865	0.9942	0.9638	0.9966	0.9943	13.9	0.7506	0.1350	1.108