Figure 1.

AD-9308 treatment ameliorated left ventricular diastolic dysfunction in streptozotocin (STZ)-induced diabetic mice. (a) flow chart illustrating the experimental design, (b) representative pulse wave and tissue Doppler echocardiograms. The (c) mean E/A ratio, (d) e’ wave, (e) E/e’ ratio, (f) e’/a’ ratio, (g) E wave deceleration time and (h) isovolumic relaxation time were measured in STZ-induced diabetic mice treated with 0, 60, 180 mg/kg/day of AD-9308 by oral gavages and non-diabetic control mice. Data are presented as mean ± SEM (n = 14–16 per group). p-for-trend was used to test thelinear trend.