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. 2021 Mar 13;10(3):450. doi: 10.3390/antiox10030450

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AD-9308 treatment improved left ventricular (LV) systolic dysfunction in streptozotocin (STZ)-induced diabetic mice. (a) representative M-mode echocardiograms. The mean (b) LV fraction shortening, (c) LV ejection fraction, (d) stroke volume, (e) cardiac output, and (f) s wave were measured in STZ-induced diabetic mice treated with 0, 60, 180 mg/kg/day of AD-9308 by oral gavages and non-diabetic control mice. Data are presented as mean ± SEM (n = 14–16 per group). p-for-trend was used to test the linear trend.