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. 2021 Mar 13;10(3):450. doi: 10.3390/antiox10030450

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AD-9308 partially normalized cardiac morphology in streptozotocin (STZ)-induced diabetic mice. The mean (a) interventricular septum thickness at end diastole, (b) leftventricular (LV) mass, (c) LV posterior wall thickness at end diastole, (d) LV internal dimension at end diastole, (e) LV internal dimension at end systole, (f) LV end diastolic volume and (g) LV end systolic volume were measured in STZ-induced diabetic mice treated with 0, 60, 180 mg/kg/day of AD-9308 by oral gavages andnon-diabetic control mice, (h) representative hemotoxylin and eosin staining of heart sections from each group. Data are presented as mean ± SEM (n = 14–16 per group). p-for-trend was used to test the linear trend. Scale bar, 20 μm.