Table 1.
Clinical data for the total study cohort and comparisons between dogs that died by six months and those alive with more than six months of follow-up.
| Variable | Total Cohort (n = 146) |
Dead by 6 Months (n = 41) |
Alive at 6 Months (n = 105) |
p-Value |
|---|---|---|---|---|
| Age (month) | 143 ± 35 | 152 ± 32 | 140 ± 36 | 0.057 |
| Weight (kg) | 9 (2–38) | 8 (2–38) | 9 (2–3) | 0.979 |
| Sex (F/M) | 58/88 | 19/22 | 39/66 | 0.410 |
| Pure breed (n [%]) | 62 (42.5) | 22 (53.7) | 40 (38.1) | 0.128 |
| No treatment (n [%]) | 56 (38.4) | 8 (19.5) | 48 (45.7) | 0.002 |
| Cardiac treatment (n [%]) | 44 (30.1) | 16 (39.0) | 28 (26.7) | 0.223 |
| Mixed treatment/disease (n [%]) | 16 (11.0) | 7 (17.1) | 9 (8.6) | 0.294 |
| Other treatment/disease (n [%]) | 30 (20.5) | 10 (24.4) | 20 (19.0) | 0.637 |
| ACVIM stage C + D (n [%]) | 51 (34.9) | 20 (48.8) | 31 (29.5) | 0.051 |
| AF (n [%]) | 5 (3.4) | 2 (4.9) | 3 (2.9) | 0.458 |
| PH (n [%]) | 18 (12.3) | 6 (14.6) | 12 (11.4) | 0.812 |
| Urea (mg/dL) | 43 (16–202) | 60 (21–202) | 40 (16–138) | 0.001 |
| Total protein (g/L) | 71.4 ± 7.8 | 70.3 ± 9.8 | 71.9 ± 6.9 | 0.266 |
| Albumin (g/L) | 29.7 ± 4.8 | 29.1 ± 5.8 | 30.3 ± 3.6 | 0.137 |
| Creatinine (mg/dL) | 1.05 (0.57–3.02) | 1.09 (0.57–2.39) | 1.05 (0.60–3.02) | 0.318 |
| WBC (103/μL) | 11.42 (4.85–48.54) | 14.02 (6.05–48.54) | 9.92 (4.85–39.31) | <0.001 |
| RBC (106/μL) | 6.92 ± 1.01 | 6.96 ± 1.26 | 6.9 ± 0.9 | 0.737 |
| Hemoglobin (g/dL) | 16.2 ± 2.4 | 16.3 ± 2.9 | 16.1 ± 2.1 | 0.667 |
| Hematocrit (%) | 46.2 ± 6.8 | 46.7 ± 8.5 | 46.0 ± 6.1 | 0.606 |
| RDW (%) | 14.0 (12.1–21.8) | 14.0 (12.2–18.9) | 13.9 (12.1–21.8) | 0.708 |
| MCV (fL) | 67.0 ± 4.3 | 67.4 ± 4.8 | 66.8 ± 4.2 | 0.499 |
| Platelet (103/μL) | 361.2 ± 135.6 | 344.7 ± 149.2 | 367.6 ± 130.0 | 0.361 |
| LA/Ao | 2.07 ± 0.68 | 2.33 ± 0.67 | 1.97 ± 0.66 | 0.004 |
| LVDDn | 1.76 ± 0.37 | 1.83 ± 0.4 | 1.74 ± 0.36 | 0.219 |
| LVSDn | 0.98 ± 0.22 | 0.99 ± 0.24 | 0.97 ± 0.21 | 0.651 |
| FS (%) | 41.9 ± 9.6 | 42.1 ± 11.9 | 41.8 ± 8.6 | 0.875 |
| E-max (cm/s) | 104.0 ± 40.0 | 115.6 ± 37.9 | 99.3 ± 40.1 | 0.027 |
| TR Vmax (m/s) | 2.72 ± 0.73 | 2.89 ± 0.8 | 2.66 ± 0.69 | 0.115 |
n: number of dogs; ACVIM: American College of Veterinary Internal Medicine; AF: atrial fibrillation; PH: pulmonary hypertension; WBC: white blood cell; RBC: red blood cell; RDW: red cell distribution width; MCV: mean corpuscular volume; LA/Ao: left atrial to aortic root diameter ratio; LVDDn: left ventricular diastolic diameter normalized for body weight; LVSDn: left ventricular systolic diameter normalized for body weight; FS: fractional shortening; E-max: trans-mitral peak E-wave velocity; TR Vmax: peak velocity of tricuspid regurgitation.