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. 2021 Mar 9;10(3):416. doi: 10.3390/antiox10030416

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DMF treatment was associated with higher antioxidant enzyme expression in the spleens of SIV-infected macaques. (A) Representative immunoblot for the antioxidant enzymes assessed. β-Actin was used as a loading control. (B,C) No significant differences in the expression of NQO1 and GPX1, respectively, were observed in the spleens with DMF treatment. (D) A significant increase in the PRDX1 expression was observed with DMF treatment. (E) No significant difference in the expression of HO-1 was observed with DMF treatment. (F) A significant increase in the HO-2 expression was observed with DMF treatment. Spleen samples from nine SIV-infected rhesus macaques (4 untreated animals and 5 DMF-treated (90 mg total DMF daily)) were analyzed using Western blotting. Each dot represents the quantified value per animal. Statistical analyses were done using Student’s unpaired t-test, ** p < 0.01. All values are expressed as mean ± SEM.