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. 2021 Mar 8;13(3):352. doi: 10.3390/pharmaceutics13030352

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CRISPR-Cas system-based genome editing to combat bacterial infection. When the target genes are ARGs, the CRISPR-Cas system can restore the sensitivity of bacteria to antibiotics, and then the drugs will kill the susceptible bacteria. When the target genes are constitutive genes of the specific resistant bacteria, then the resistant bacteria will be killed. When the target genes are host chromosomal DNA that is cytotoxic to the resistant bacteria, the target cell will die because of the excision of the genome.