Figure 2.

Immunosuppression Burden (A) Reversible multistate modeling the instantaneous probability of being in 1 of 3 states: (1) alive, off immunosuppression (off immunosuppression, yellow zone), (2) alive, on immunosuppression (immunosuppression, green zone), or (3) dead (death, orange zone). All patients begin in state 1 on day +5 after transplant, after receiving cyclophosphamide 50 mg/kg on days +3 and +4. Patients may have reversible transition between states (1) and (2) but death was an absorbing state. (B) Nonreversible multistate modeling the instantaneous probability of being in 1 of five states: (1) alive, on immunosuppression (IS), (2) alive, off first IS, (3) alive, on second IS, (4) alive, off subsequent IS, or (5) Dead.