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ApoE contains the N-terminal domain which contains the receptor-binding region and the C-terminal domain containing the lipid-binding region. There are three isoforms of APOE: ApoE2, ApoE3, and ApoE4. ApoE2 contains Cys residues at positions 112 and 158. ApoE3 contains a Cys residue at position 112 and an Arg residue at 158. ApoE4 contains Arg residues at both of these positions. Abbreviations: cysteine (Cys), arginine (Arg), apolipoprotein E(ApoE).
