Table 1.
Encapsulation efficiency (EE) and drug loading (DL) before and after loading NPs in microparticles (MPs) (n = 3, mean ± SD).
| Feeding Amount of MET (mg) |
PLGA MPs | Alginate NPs before Adding to PLGA MCs |
Alginate NPs Coated with Chitosan before Adding to PLGA MCs |
Alginate NPs Coated with Chitosan after Adding to PLGA MCs |
|---|---|---|---|---|
| 1 | 35.1 ± 2.7% | 79.1 ± 2.7% | 75.2 ± 3.2% | - |
| (DL: 0.35) | (DL: 0.79) | (DL: 0.75) | ||
| 2 | 33.6 ± 5.1% | 74.4 ± 5.1% | 73.1 ± 2.8% | - |
| (DL: 0.67) | (DL: 1.48) | (DL: 1.46) | ||
| 4 | 28.2 ± 4.2% | 71.3 ± 4.2% | 70.3 ± 4.5% | 65.2 ± 3.7% |
| (DL: 1.1) | (DL: 2.85) | (DL: 2.81) | (DL: 1.83) | |
| 6 | 25.7 ± 3.4% | 53.6 ± 3.4% | 50.1 ± 6.1% | - |
| (DL: 1.54) | (DL: 3.21) | (DL: 3.01) | ||
| 8 | 15.4 ± 4.5% | 32.5 ± 4.5% | 30.2 ± 4.7% | - |
| (DL: 1.23) | (DL: 2.60) | (DL: 2.41) |