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. 2021 Mar 11;14(3):254. doi: 10.3390/ph14030254

Figure 3.

Figure 3

The effect of DOX, CQ, and TIC single or combinations treatments on DNA Damage. Comet assay represents genotoxicity of selected single or combined drugs causing nuclear DNA Damage and photomicrographs of MCF-7 cells (I-A) and MCF-7 Xenograft mice (II-A). Computed comet tail length (µm) representing DNA damage in MCF-7 cells (I-B) or MCF-7 Xenograft mice (II-B). The percent of fragmented DNA measured colorimetric using Diphenylamine reagent estimated in all treated groups of MCF-7 cells (I-C) and MCF-7 Xenograft mice (II-C). Results are expressed as mean ± SE (n = 3). # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 compared with control (untreated group). + p < 0.05, ++ p < 0.01, +++ p < 0.001, ++++ p < 0.0001 compared with the DOX treated group.