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. 2021 Mar 12;57(3):261. doi: 10.3390/medicina57030261

Table 2.

Pathways enriched by subtype-specific genes using Reactome.

Pathway p-Value
29 Luminal A-Specific Genes
SUMOylation of SUMOylation proteins 0.003
SUMOylation of ubiquitinylation proteins 0.004
Defective intrinsic pathway for apoptosis due to p14ARF loss of function 0.004
90 Luminal B-Specific Genes
Cellular senescence 0.005
Oxidative stress induced senescence 0.001
Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.001
40 HER2-Specific Genes
Aryl hydrocarbon receptor signaling 0.0003
VxPx cargo-targeting to cilium 0.003
Amplification of signal from the kinetochores 0.004
23 Basal-Specific Genes
Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.0002
Activation of gene expression by SREBF (SREBP) 0.004
Metabolism of steroids 0.004