Table 1.
Different kind of polymer shell using to coat SPIONs. A: core size with shell (Transmission Electron Microscopy), B: hydrodynamic size with shell (Dynamic Light Scattering), An: naked core size, Bn: naked hydrodynamic size.
| Shell Composition | Size (nm) | Experimental Model | Drugs, Agent |
|---|---|---|---|
| Polyethylene-glycol (PEG) [18,40,47,50,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72] | 4–101.6 (A) 8–1000 (B) 7.5–2-10.3 (An) 22 (Bn) |
In vitro In vivo (rat, mouse) |
Methotrexate, Transferrin, Anti- Transferin receptor ab, Bacterial nanocellulose, anti-IL-1beta-mab, nutlin-3a, Cisplatin, anti-Ape1 siRNA, Temozolomine, anti-nestin ab, Rituximab, Doxorubicin, folic acid, Indocyanine green, O6-benzylguanine, Chlorotoxin-RNAi, Transactivating-transduction protein |
| Polyethylenimine (PEI) [40,56,57,58,59,73,74] | 4–10.3 (A), 11.6–186.5 (B) 10 (An) |
In vitro In vivo (rat) |
Complementary DNA, Paclitaxel, Bacterial nanocellulose, anti-Ape1 siRNA, Chlorotoxin-RNAi |
| Poly(lactide-co-glycolide), (PLGA) [43,46,63,74,75,76,77,78,79] | 8.4–178.6 (A) 71.8–482.8 (B) 11.5–84.4 (An) 36.8 (Bn) |
In vitro In vivo (guinea pig, mouse, rat) |
Methotrexate, Paclitaxel, Adipose-derived stem cells, Temozolomide, Doxorubicin, anti-Nestin ab, Transferrin, polysorbate-80, 5-iodo-2-deoxyuridine, Paclitaxel |
| Polyvinyl alcohols, PVA [80,81,82] | 8–12 (A) 30–99.3 (B) 5–10 (An) |
In vitro In vivo (mouse) |
No |
| Aniline-co-N-(1-one-butyric acid) aniline (SPAnH) [83] | - | In vitro In vivo (rat) |
1,3-bis(2-chloroethyl)-1-nitrosourea |
| Poly(γ-glutamic acid-co-distearyl γ-glutamate) [76] | 106.5 (A) 110 (B) |
In vitro In vivo (mouse) |
Paclitaxel, Adipose-derived stem cells |
| Polybutulcyanoacrylate, PBCA [84] | 124.5–148.7 (A) | In vitro | Brain-derived neurotrophic factor |
| Poly-L-lysine [85] | 443.4 (B) | In vitro | No |
| Poly-(dimethylamine-co-epichlorhydrin-co-ethylendiamine), PEA [86] | 10 (A) 47.5 (B) |
In vitro | No |
| Chitosan [36,40,59,68,87] | 4–6 (A), 40–300 (B), 6–10 (An) |
In vitro In vivo (mouse, zebrafish, rat) |
anti-Ape1 siRNA, Prednisolone, Chlorotoxin-RNAi, O6-benzylguanine |
| Dextran, Carboxydextran [80,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104] | 4–130 (A), 23–150 (B) 4.7–10 (An) 144.2–181.2 (Bn) |
In vitro In vivo (mouse, zebrafish, rat) Routine clinical use |
Quercetin, Transferrin, lipolysaccharide, Folate-Paclitaxel, Rhodamine 123, Epirubicin, cmHsp70.1 mab, recombinant Interleukin-1 receptor antagonist, Doxorubicin, Monocyte-derived-macrophage, Cyclic pentapeptide c -chlorotoxin |