Table 2.
The MSDIN gene family in Amanita exitialis.
| Leader Peptide | Core Peptide | Recognition Sequence | Monoisotopic Mass |
|---|---|---|---|
| MSDINATRLP | IWGIGCNP | CVGDDVTSVLTRGEA | 918.3541(α-amanitin) |
| MSDINATRLP | IWGIGCDP | CVGDDVTALLTRGEA | 919.3382(β-amanitin) |
| MSDINATRLP | AWLVDCP | CVGDDVNRLLTRGE | 846.3217(phallacidin) |
| MSDINATRLP | AWLTDCP | CVGDDVNRLLTRGE | 786.3371 |
| MSDINTTRLP | FVFVASPP ★ | CVGDDIAMVLTRGE | 844.4483 |
| MSDINTARLP | FIWVFGIP | --GDDIGTVLTRGEK | 959.5269 |
| MSDINLTRLP | GIIAIIP | CVGDDDDVNSTLTRGQ | 677.4476 |
| MSDINATRLP | IILAPVIP | CISDDNDP--TLTRGQ | 816.5473 |
| MSDINTARLP | IPIPPFFFP | FVSDDIEIVLRRGEK | 1055.5844 |
| MSDINTARLP | IPIPPFFFP | FVSDDIEIVLRRGEK | 1055.5844 |
| MSDINATRLP | IGRPQLLP | CVGGDVNYILISGEK | 874.5389 |
| MSDINPTRLP | IFWFIYFP | CVSDVDST-LTRGE | 1113.5688 |
| MSDINTARLP | IYRPPFYALP | CVGDDIQAVLTRGE | 1217.6597 |
| MSDINTARLP | IIWIIGNP | CVSDDVERILTRGE | 906.5327 |
| MSDINVIRAP | LLILSILP | CVGDDIEV-LRRGE | 862.5892 |
| MSDINATRLP | LFFPPDFRPP ★ | CVGDADNFTLTRGEK | 1213.6284 |
| MSDINATRLP | LFFPPDFRPP ★ | CVGDADNFTLTRGE | 1213.6284 |
| MSDINVIRLP | SMLTILPP | CVSDDASNTLTRGE | 852.4779 |
| MSDINTARLP | VFSLPVFFP ★ | --SDDIQAVLTRGE | 1033.5637 |
| MSDINVTRLP | VFIFFFIPP | CVGDGTADIVRKGEK | 1107.6157 |
| MSDINATRLP | VWIGYSP | CVGDDCIALLTRGE | 802.4014 |
| MSDINATRLP | VWIGYSP | CVGDDCIALLTRGE | 802.4014 |
| MTDINDTRLP | FIWLLWIWLP | SVGDD-NNILNRGEE | 1367.7794 |
★ and underlined letters show novel and known cyclic peptides detected with MS and MS/MS. The monoisotopic masses are for unmodified cyclic peptides based on MSDIN core peptides, except for major toxins (α-amanitin, β-amanitin and phallacidin). Core peptides are indicated in bold.