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The inhibition mechanisms of direct oral anticoagulants (DOACs). Dabigatran is direct thrombin inhibitor, other DOACs including rivaroxaban, apixaban, edoxaban, and betrixaban are direct factor Xa inhibitors. DOACs inhibit coagulation factors directly. On the other hand, heparin indirectly inhibits coagulation factors through AT and warfarin affects to the coagulation factor synthesis.
