Table 1.

Brands of clear aligners currently used in Italy with the main basic information and number of scientific studies in which they are used.

Name	Manufacturer	Material	Introduction	Daily/Weekly Wearing Time	Indications	Contraindications	Attachments	Divots	Gingival Margin Design	Auxiliaries	Studies
AirNivol	AirNivol	PU * or PET-G **	2010	22 h/14 days	Diastema, crowding, class II and III, deep bite, open bite, crossbite, preprosthetic and presurgical orthodontics	None	Yes	Yes	straight at the gingival zenith	Yes	3
ALL IN	Micerium S.p.A.	PET-G	2010	22 h/14 days	Diastema, crowding, open bite, cross bite, intrusion, extrusion, class I, II, III malocclusions	None	Yes	No	scalloped		1
ArcAngel	Network Gruppo Dextra	PET-G	2011	22 h/14 days	Diastema, crowding, rotation, intrusion/extrusion, orthodontic relapse	Class II and III need a surgical approach, severe cross bite, excessive buccal/lingual	Yes	No	scalloped	No	1
Clear Aligner	Scheu Dental	PET-G	2013	17 h/14 days	Diastema, crowding, rotation, torque control, orthodontic relapse	No patient compliance	Yes	Yes	straight 2 mm up the gingival zenith	Yes	10
Dair	Orthovit Devices	PU or PET-G	2010	23 h/14 days	Diastema, rotation, crowding	Severe malocclusion or periodontal problems	Yes	No	straight at the gingival zenith	No	0
Dental Stealth	Function Research srl	PU or PET-G	2008	22 h/15 days	Diastema, crowding, intrusion/extrusion, deep bite/open bite	None	Yes	No	scalloped	No	0
Effect Aligners	Orthofan	PET-G and PE ***	1998	22 h/14 days	Class I, II, III malocclusions, diastema, crowding, rotation, deep bite, open bite, asymmetry	No patient compliance or bad hygiene	Yes	No	scalloped	No	0
F22	Sweden & Martina Spa	PU	2010	22 h/14 days	All the malocclusions	No patient compliance	Yes	Yes	straight at the gingival zenith	Yes	9
Instaligner	CP Laboratorio Ortodontico	PET-G	2010	22 h/20 days	Diastema, crowding, intrusion/extrusion	TMJ **** disorders, severe skeletal problems	Yes	No	scalloped	No	0
Invisalign	Align Tech	Smart Track (multilayer aromatic thermoplastic polyurethane	1998	22 h/14 days	All the malocclusions	No patient compliance	Yes	No	scalloped	Yes	110
Inwisible	Wilocs	PET-G	2010	22 h/14 days	Diastema, crowding, rotation, intrusion/extrusion, light distal movements	Extractive cases, skeletal crossbites	Yes	No	scalloped	Yes	0
Nuvola	G.E.O. srl	PU	2006	20 h/10–15 days	Diastema, crowding, II Class malocclusion, cross bite, deep bite	Skeletal crossbites, severe vertical/trasversal problems	Yes	No	scalloped	Yes	2
Orthocaps	Ortho Caps Gmbh	Dual layer polymer 2006		20 h/14 days	All the malocclusions	No patient compliance	Yes	No	scalloped	Yes	0
Smart Evolution	Ortho Evolution srl	PE	2009	customized	All the malocclusions including those needing transversal palatal expansion	None	Yes	No	scalloped	No	0
Smile Clear	Orthodontics High Design	PET-G	2012	22 h/15 days	Crowding, crossbite, deep bite, open bite, orthodontic relapse, preprosthetic orthodontics	Class III malocclusions	Yes	Yes	scalloped	Yes	0
SmileLine	SmileLine	PET-G	2009	22 h/10–15 days	Light and moderate malocclusions	Severe malocclusions	Yes	No	scalloped	Yes	0
Smilers	Biotech Dental	PET-G	2014	22 h/15 days	Diastema, crowding, occlusal problems, TMJ disorders	Periodontal problems	Yes	No	scalloped	No	0
Smiletech	Ortodontica Italia srl	PU/PET-G	1999	22 h/15 days	Diastema, crowding, deep bite, open bite, preparation/finalization maxillo-facial surgery	None	Yes	No	scalloped	Yes	1
Sorridi	Tecnologia Dentale	PET-G	2015	22 h/7 days	Crowding, class I, II and III malocclusions, surgical-orthodontic cases	No patient compliance	No	Yes	straight 2 mm up the gingival zenith	Yes	1

Note: * PU = Polyurethane; ** PET-G = Polyethylene terephthalate glycol; *** PE = Polyester; **** TMJ = temporomandibular joint.