Table 1.
Relevant pharmacogenetic variants in cytochrome P450 enzymes 1.
| Pharmacogene | Variants | Clinical Function |
|---|---|---|
| CYP2C8 | *1A | Normal function |
| *5, *7, *11 | No function | |
| CYP2D6 | *1, *2, *27, *33, *34, *35, *39, *45, *46, *48, *53 | Normal function |
| *9, *10, *17, *29, *41, *49, *50, *54, *55, *59 | Decreased function | |
| *3, *5, *6, *7, *8, *11, *12, *13, *14, *15, *18, *19, *20, *21, *31, *36, *38, *40, *42, *44, *47, *51, *56, *57, *60, *62, *68, *69, *81, *92, *96, *99, *100, *101, *114, *120, *124, *129 | No function | |
| CYP3A4 | *1A | Normal function |
| *8, *11, *13, *16A, *17, *22 | Decreased function | |
| CYP3A5 | *1A, *1D | Normal function |
| *3, *6, *7 | No function |
1 Data from Pharmacogene Variation Consortium at pharmvar.org, accessed on 19 February 2021.