Table 2.
Pharmacogenetic variants described for dexamethasone response 1.
| Pharmacogene | Name | Variant | Drug Phenotype |
|---|---|---|---|
| ABCB1 | ATP Binding Cassette Subfamily B Member 1 | rs2032582 rs1045642 |
Efficacy 2 Efficacy 2 |
| DOK5 | Docking Protein 5 | rs117532069 | Toxicity 3 |
| SERPINE1 | Serpin Family E Member 1 | rs6092 | Toxicity 3 |
| LINC00251 | Long Intergenic Non-Protein Coding RNA 251 | rs141059755 | Toxicity 3 |
| BMP7 | Bone Morphogenetic Protein 7 | rs79085477 | Toxicity 3 |
| PYGL | Glycogen Phosphorylase L | rs7142143 | Efficacy 4 |
| DOK5 | Docking Protein 5 | rs117532069 | Toxicity 3 |
| CTNNB1 | Catenin Beta 3 | rs4135385 | Efficacy 4 |
1 Data from PharmGKB (pharmgkb.org, accessed on 19 February 2021), 2 Survival in multiple myeloma, 3 Risk of osteonecrosis in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma, 4 Risk of relapse in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma.