Table 4.

Ligands and target genes of the nuclear receptor PXR [80,82,86].

Nuclear Receptor	Drug Ligands	Target Genes
PXR	Amoxicillin, ampicillin, penicillin, cefuroxime, cephalexin, cefradine, sulfamethazine, erythromycin, rifampin, tetracycline, topiramate, carbamazepine, phenytoin, valproic acid, terbinafine, griseofulvin, clotrimazole, miconazole, nifedipine, cyclophosphamide, cisplatin, docetaxel, paclitaxel, vinblastine, troglitazone, rosiglitazone, atorvastatin, simvastatin, efavirenz, nevirapine, ritonavir, omeprazole, lansoprazole	CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CES2, UGT1A1, UGT1A6, ABCB1, ABCC2