Table 1.
Minimum inhibitory concentration (MIC) 1 and minimum bactericidal concentration (MBC) 1 of celastrol and pristimerin, expressed in μg/mL against different microorganisms 2.
| Microorganisms | Celastrol | Pristimerin | ||
|---|---|---|---|---|
| MIC | MBC | MIC | MBC | |
| Bacillus subtilis | 0.156 | 2.5 | 1.25 | 10 |
| B. cereus | 0.625 | 2.5 | 10 | >40 |
| B. pumilus | 0.625 | 2.5 | 2 | 10 |
| B. megaterium | 1.25 | 5 | 20 | >40 |
| Staphylococcus aureus | 1.25 | >40 | >40 | >40 |
| S. epidermidis | 0.312 | 15 | 1.25 | >40 |
| S. saprophyticus | 2.5 | 10 | 10 | 10 |
| Mycobacterium smegmatis | 5 | >40 | >40 | >40 |
| Enterococcus faecalis | 1.25 | 40 | 20 | >40 |
1 Values represent average obtained from a minimum of three experiments. 2 The quinone compounds were inactive against Gram-negative bacteria and the yeast assayed (MIC > 40 µg/mL).