Table 1.
Meta-analysis of the association between autophagy-related variants and CRC risk in the DACHS and CRCGen populations.
| Gene | Variant_dbSNP | Risk Allele | DACHS Cohort (n = 7998) | CRCGen Cohort (n = 2024) | Meta-Analysis (n = 10,022) | pHet | |||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) a | p-Value | OR (95% CI) a | p-Value | OR (95% CI) a | p-Value | ||||
| NRG3 | rs11196336 | C | 1.18 (1.10–1.28) | 0.00002 | 1.09 (0.93–1.28) | 0.3125 | 1.17 (1.09–1.25) | 0.0000185 | 0.354 |
| DAPK2 | rs11631973 | G | 1.15 (1.06–1.24) | 0.00060 | 1.17 (1.00–1.36) | 0.0563 | 1.15 (1.07–1.23) | 0.0000799 | 0.846 |
| EGFR | rs2075108 | A | 1.15 (1.03–1.28) | 0.01308 | 1.39 (1.11–1.73) | 0.0035 | 1.19 (1.08–1.31) | 0.000457 | 0.134 |
| TP73 | rs4648553 | A | 1.10 (1.02–1.18) | 0.01103 | 1.21 (1.05–1.39) | 0.0104 | 1.12 (1.05–1.20) | 0.000590 | 0.254 |
| LOC100128105 | rs6565506 | C | 1.09 (1.01–1.17) | 0.02129 | 1.21 (1.04–1.41) | 0.0122 | 1.11 (1.04–1.19) | 0.001597 | 0.214 |
| ATG5 | rs546456 | T | 1.09 (1.03–1.16) | 0.00574 | 1.10 (0.97–1.25) | 0.1324 | 1.09 (1.03–1.16) | 0.001700 | 0.918 |
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval. Estimates were adjusted for age, sex, and principal components. Significant results are in bold after correction for multiple testing considering a significant threshold of 0.00027. a Association estimates were calculated according to a log-additive model of inheritance.