Figure 2.

Schematic representation of metabolic pathways in oligodendroglial cells. Those indicated in red (glycolysis, pentose phosphate pathway, and hexosamine pathway) require glucose. The pathways circled in blue (fatty acid synthesis, Kreb’s cycle, and oxidative phosphorylation ( electron transport chain)) can also be fueled by alternative sources of energy, namely lactate, ketone bodies, and N-acetyl aspartate (NAA).