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Vaccine strategies to increase stalk-directed immunity. Strategies used to induce stalk-directed immunity, such as hyperglycosylation of the HA [30,31,32], development of a headless HA [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47], expression of the LAH fragment alone [48,49,50], and chimeric [51,52,53,54,55,56,57,58,59,60,61,62] and mosaic [63,64] HA proteins, have been illustrated and briefly described here.
