Table 1.
Baseline characteristics of 1043 patients with positive HCV Ab.
| GENE | Gentype | Total (n = 1043) | CHC (n = 934) | Spontaneous HCV Clearance (n = 109) |
p Values (CHC vs. SHC) |
|
|---|---|---|---|---|---|---|
| Female, n (%) | 520 (49.9) | 449 (48.1) | 71 (65.1) | 0.001 | ||
| Age (years old) | 57.0 ± 12.95 | 57.1 ± 12.8 | 54.3 ± 13.9 | 0.031 | ||
| Mixed cryoglobulinemia, n (%) | 589 (56.5) | 550 (58.9) | 39 (35.8) | <0.001 | ||
| Log HCV RNA (logIU/mL) | 6.04 ± 1.01 | 6.04 ± 1.00 | NA | |||
| HCV genotype | ||||||
| Genotype 1, n (%) | 550 (52.7) | 500 (53.5) | NA | |||
| Genotype 2, n (%) | 300 (28.8) | 300 (32.1) | NA | |||
| Others, n (%) | 134 (12.8) | 134 (14.3) | NA | |||
| ALT(U/L) | 88.3 ± 99.42 | 93.6 ± 102.0 | 42.2 ± 54.3 | <0.001 | ||
| rs12979860, n (%) | IFNL3 | CC | 891 (85.4) | 791 (84.7) | 100 (91.7) | 0.01 |
| rs6486122, n (%) | ARNTL | TT | 224 (21.4) | 207 (22.2) | 17 (15.6) | 0.09 |
| rs1045642, n (%) | ABCB1 | GG | 422 (40.5) | 377 (40.4) | 45 (41.3) | 0.399 |
| rs9461776, n (%) | HLA-II | AA | 871 (83.3) | 791 (84.7) | 80 (73.4) | 0.003 |
| rs2071286, n (%) | NOTCH4 | CC | 774 (74.2) | 701 (75.1) | 73 (67) | 0.083 |
| rs6976053, n (%) | SERPINE1 | CC | 292 (27.9) | 289 (30.9) | 3 (2.8) | <0.001 |
| rs11128603, n (%) | PPARG | TT | 943 (90.2) | 850 (91.0) | 93 (85.3) | 0.44 |
| rs61330082, n (%) | NAMPT | TT | 178 (17) | 166 (17.8) | 12 (11) | 0.46 |
| rs10953502, n (%) | NAMPT | TT | 599 (57.3) | 554 (59.3) | 45 (41.3) | 0.132 |
| rs2302559, n (%) | NAMPT | CC | 624 (59.7) | 576 (61.7) | 48 (44) | 0.14 |
| rs2058539, n (%) | NAMPT | AA | 608 (58.2) | 562 (60.2) | 46 (42) | 0.297 |
| rs1423096, n (%) | RETN | CC | 670 (64.2) | 595 (63.7) | 75 (69.2) | 0.92 |
| rs1477341, n (%) | RETN | AA | 343 (32.9) | 308 (33.0) | 35 (32.1) | 0.332 |
HCV: hepatitis C virus; CHC: chronic hepatitis C virus infection; SHC: Spontaneous HCV clearance; ALT: alanine transaminase; IFNL3: interferon-λ 3; ARNTL: aryl hydrocarbon receptor nuclear translocator-like protein 1; ABCB1: ATP binding cassette subfamily B member 1; HLA II: human leukocyte antigen class II; NOTCH4: neurogenic locus notch homolog protein 4; SERPINE1: serpin family E member 1; PPARG: peroxisome proliferator-activated receptor gamma; NAMPT: Nicotinamide phosphoribosyltransferase; RETN: resistin; NA: not assessable.