Table 3.
Genetic associations with baseline HCV RNA positivity.
| Reference Allele/Risk Allele | Univariate Analyses | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI OR | p Values | OR | 95% CI OR | p Values | ||
| Baseline MC (0,1) | 2.618 | 1.726–3.969 | <0.001 | 2.617 | 1.679–4.079 | <0.001 | |
| rs12979860- | C/T | 3.72 | 1.397–9.905 | 0.009 | 3.755 | 1.378–10.235 | 0.01 |
| rs1045642- | G/A | 1.164 | 0.856–1.582 | 0.332 | |||
| rs9461776 | G/A | 1.751 | 1.125–2.276 | 0.013 | 1.783 | 1.106–2.876 | 0.018 |
| rs2071286 | C/T | 0.656 | 0.441–0.974 | 0.037 | 0.711 | 0.468–1.08 | 0.11 |
| rs6976053 | T/C | 2.871 | 2.045–4.131 | <0.001 | 2.737 | 1.93–3.881 | <0.001 |
| rs6486122 | C/T | 0.942 | 0.725–1.224 | 0.657 | |||
| rs11128603- | G/A | 0.744 | 0.29–1.911 | 0.539 | |||
| rs61330082- | C/T | 0.9 | 0.603–1.343 | 0.605 | |||
| rs2302559- | C/T | 1.867 | 0.859–4.056 | 0.115 | |||
| rs10953502- | C/T | 1.243 | 0.591–2.616 | 0.567 | |||
| rs2058539- | C/T | 0.519 | 0.232–1.162 | 0.111 | |||
| rs1423096- | C/T | 1.182 | 0.48–2.906 | 0.716 | |||
| rs1477341- | A/T | 0.728 | 0.191–2.772 | 0.642 | |||
MC: mixed cryoglobulinemia; IFNL3: interferon λ3; ABCB1: ATP binding cassette subfamily B member 1; HLA II: Human leucocyte antigen class II; NOTCH4: neurogenic locus notch homolog protein 4; SERPINE1: Serpin Family E Member 1; ARNTL: aryl hydrocarbon receptor nuclear translocator like; PPARG: peroxisome proliferator-activated receptor gamma; NAMP: Nicotinamide phosphoribosyltransferase; RETN: resistin; OR: odds ratio. p value for Hosmer-Lemeshow test: 0.963.