Table 5.
Genetic associations with 24-week post-therapy mixed cryoglobulinemia in SVR patients.
| Reference Allele/Risk Allele | Univariate Analyses | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI OR | p Values | OR | 95% CI OR | p Values | ||
| Pre-therapy mixed cryoglobulinemia | 3.143 | 2.16–4.575 | <0.001 | 3.113 | 1.895–5.116 | <0.001 | |
| rs12979860 | T/C | 1.283 | 0.763–2.159 | 0.348 | |||
| rs1045642 | G/A | 1.031 | 0.774–1.372 | 0.835 | |||
| rs9461776 | G/A | 1.068 | 0.649–1.757 | 0.797 | |||
| rs2071286 | C/T | 1.035 | 0.678–1.58 | 0.874 | |||
| rs6976053 | C/T | 0.933 | 0.746–1.166 | 0.541 | |||
| rs6486122 | C/T | 1.024 | 0.802–1.308 | 0.85 | |||
| rs11128603 | G/A | 1.414 | 0.585–3.42 | 0.442 | |||
| rs61330082 | C/T | 0.857 | 0.64–1.147 | 0.299 | |||
| rs2302559 | C/T | 1.142 | 0.734–1.776 | 0.557 | |||
| rs10953502 | C/T | 1.013 | 0.588–1.743 | 0.964 | |||
| rs2058539 | C/T | 0.989 | 0.601–1.627 | 0.965 | |||
| rs1423096 | C/T | 0.652 | 0.45–0.944 | 0.023 | 0.677 | 0.46–0.995 | 0.047 |
| rs1477341 | A/T | 0.794 | 0.589–1.072 | 0.132 | |||
SVR: sustained virological response; IFNL3: interferon λ3; ABCB1: ATP binding cassette subfamily B member 1; HLA II: Human leucocyte antigen class II; NOTCH4: neurogenic locus notch homolog protein 4; SERPINE1: Serpin Family E Member 1; ARNTL: aryl hydrocarbon receptor nuclear translocator like; PPARG: peroxisome proliferator-activated receptor gamma; NAMP: Nicotinamide phosphoribosyltransferase; RETN: resistin; OR: odds ratio; CI; confidence interval.