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. 2021 Mar 11;13(6):1234. doi: 10.3390/cancers13061234

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Specific protein damages in tumor tissues (T) compared to non-tumor tissues (NT) in early-onset patients (EOP) and late-onset patients (LOP). (a) Principal component analysis (PCA) of total protein expression from each spot analyzed by 2D-DIGE. Lower panel: Venn diagram of specific spots from EOP and LOP, (b) PCA of carbonylated protein expression from each spot analyzed by 2D-DIGE. Lower panel: Venn diagram of specific spots from EOP and LOP. (c–f)—String software analysis of significant differential proteins (c) Down regulated in EOP; (d) Down regulated in LOP; (e) More carbonylated in EOP; (f) More carbonylated in LOP.