Table 2.

Uni- and Multivariate analysis of Overall survival (OS) and Progression-free (PFS) survival of EOP and LOP from our multi-centric cohort.

Cohort features n = 255	Univariate PFS EOP <55 y.o. (106)			Univariate PFS LOP >70 y.o. (149)			Multivariate PFS LOP >70 y.o. (149)			Univariate OS EOP <55 y.o. (106)			Univariate OS LOP > 70 y.o. (149)
Age Group	HR	95% Ci	p *	HR	95% Ci	p *	HR	95%Ci	p *	HR	95%Ci	p *	HR	95%Ci	p *
Sex (Men)	0.79	0.49–1.27	0.335	0.841	0.56–1.26	0.405				0.956	0.58–1.57	0.86	0.786	0.52-.13	0.187
Age	1.023	0.97–1.07	0.396	0.944	0.88–1.00	0.084				1.013	0.96–1.06	0.638	0.985	0.93–1.04	0.611
T						0.023						0.954
T1	0.883	0.27–2.81	0.834	0.2	0.02–1.42	0.11	0.326	0.04–2.39	0.273	1.131	0.35–3.62	0.837	0.266	0.03–1.89	0.189
T2	0.656	0.32–1.32	0.24	0.583	0.32–1.04	0.072	0.706	0.38–1.28	0.255	0.931	0.47–1.83	0.837	0.716	0.42–1.22	0.223
T3	1	1	1	1	1	1	1	1	1	1	1	-	1	1	1
N0/N1	1.639	0.96–2.79	0.071	2.697	1.52–4.75	0.0007	2.53	1.11–4.54	0.002	0.571	0.32–1.02	0.06	0.415	0.24–0.71	0.002
Tumor differentiation n = 255						0.015
Well	0.875	0.50–1.50	0.634	1	1	1	1	1	1	0.942	0.52–1.68	0.841	1	1	1
Moderate	1	1	1	1.787	1.13–2.82	0.013	1.738	1.09–2.76	0.02	1	1	1	1.18	0.76–1.83	0.459
Poorly	1.215	0.65–2.26	0.542	1.966	1.14–3.38	0.015	2.14	1.23–3.71	0.006	1.343	0.696–2.59	0.382	1.65	0.96–2.83	0.068
Unknown	0.841	0.20–3.49	0.813	0.451	0.06–3.25	0.432	0.893	0.11–6.77	0.913	1.525	0.46–5.00	0.488	0.728	0.17–2.99	0.662
Tumor size	1.005	0.99–1.01	0.436	1.008	0.99–1.02	0.147				1.003	0.98–1.02	0.747	1.008	0.99–1.01	0.122
Vascular invasion	1.43	0.99–2.0	0.054	1.35-	0.88–1.45	0.322				1.508	1.03–2.19	0.032	1.064	0.83–1.36	0.619
Perinervous invasion	1.246	0.72–2.13	0.425	1.42	0.98–2.07	0.061				0.999	0.57–1.75	0.999	1.295	0.90–1.85	0.158

*: Cox proportional hazard regression.