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. 2021 Mar 15;12(3):419. doi: 10.3390/genes12030419

Table 4.

Significant pathway-level eQTLs in the brain or blood by aggregating cis rare variants.

CHR Begin
Position		 End
Position		 Gene CVAR + Unique
VAR ^		 p-Value Gene
Module		 Pathway
17 31,600,172 33,592,552 CCL7 * 340 206 1.84 × 10−5 16 Inflammation mediated by chemokine and cytokine signaling
17 31,648,819 33,621,655 CCL8 * 319 195 4.50 × 10−4 16 Inflammation mediated by chemokine and cytokine signaling
17 72,322,351 74,401,630 GRB2 1108 717 6.04 × 10−7 14 Inflammation mediated by chemokine and cytokine signaling
2 217,992,496 220,001,949 CXCR2 943 564 1.53 × 10−6 14 Inflammation mediated by chemokine and cytokine signaling
5 174,085,268 176,108,976 HRH2 335 196 9.07 × 10−6 5 Histamine H2 receptor mediated signaling
1 25,859,096 27,901,441 RPS6KA1 1208 790 1.01 × 10−5 5 Ras Pathway, CCKR signaling map
11 76,033,278 78,180,311 PAK1 565 355 1.83 × 10−5 5 Ras Pathway, CCKR Signaling map
21 33,696,834 35,718,581 IFNAR1 525 332 1.98 × 10−5 14 Inflammation mediated by chemokine and cytokine signaling
3 11,628,812 13,702,170 RAF1 431 255 2.11 × 10−5 14 Inflammation mediated by chemokine and cytokine signaling
1 83,964,144 85,961,982 GNG5 589 336 3.43 × 10−5 5 Histamine H2 receptor mediated signaling
9 115,150,150 117,160,754 ALAD 620 425 4.97 × 10−5 6 Heme biosynthesis
1 44,478,672 46,476,606 UROD 1061 649 5.92 × 10−5 6 Heme biosynthesis
19 13,202,507 15,228,794 PRKACA 767 501 7.60 × 10−5 5 Histamine H2 receptor mediated signaling, CCKR signaling map
9 127,005,465 128998618 HSPA5 1235 692 7.91 × 10−5 15 Parkinson disease
8 21,946,761 23968794 TNFRSF10C 817 520 8.77 × 10−5 5 Apoptosis signaling
19 51,273,985 53272173 FPR2 440 280 1.23 × 10−4 14 Inflammation mediated by chemokine and cytokine signaling
13 30,317,837 32,332,540 ALOX5AP 297 197 1.26 × 10−4 14 Inflammation mediated by chemokine and cytokine signaling
2 200,984,212 203,030,077 CFLAR 637 404 2.42 × 10−4 5 Apoptosis signaling
17 39,458,200 41,463,831 STAT5A 1093 708 3.08 × 10−4 12 PDGF signaling
14 50,190,597 52,294,891 NIN 516 323 3.65 × 10−4 12 PDGF signaling
12 49,108,257 51,158,233 TMBIM6 1082 716 4.48 × 10−4 5 Apoptosis signaling

+ Cumulative number of variants; ^ Number of unique variants; * Results from brain (otherwise results from blood); Chromosome and map position according to GRCh37 assembly.