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. 2021 Mar 16;22(6):3019. doi: 10.3390/ijms22063019

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PR increased the volume of OVCAR8 spontaneously-formed single spheroids and decreased their growth inhibition due to CDDP, CBDCA and PTX. Three-day-old OVCAR8 spheroids were treated with increasing concentrations of PR for 24 hours, then for an additional 3 days with CDDP, CBDCA and PTX. (A) Responses were evaluated by measuring the volume of at least three spheroids. (B) Representative phase-contrast microphotographs showing the volume of OVCA8 spheroids treated with PR, drugs and the combination drugs/PR. Data are expressed as mean ± SD of three replicates with three different PR pools and represent the percentage with respect to control medium. * p < 0.05 (untreated vs. PR-treated cells).