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. 2021 Mar 12;22(6):2905. doi: 10.3390/ijms22062905

Figure 2.

Figure 2

Model of Vps13 membrane targeting determinants. The Vps13 lipid transport channel bridges organelle membranes at contact sites through membrane targeting determinants on either end. An N-terminal helix in the chorein domain is predicted to target membranes. Within the C-terminus, the six-repeat Vps13 Adaptor Binding (VAB) domain binds proline-X-proline (PxP) motif-containing adaptors at a site within repeats 5–6. Additional C-terminal conserved APT1, Autophagy-related protein 2 C-terminal (ATG2_C) and Pleckstrin homology (PH) domains have putative membrane targeting roles that may function cooperatively to position the lipid transport channel. Arrows indicate the presumed direction of lipid transport along a hydrophobic groove shown by dotted lines. The N- and C-termini of Vps13 are indicated. Model not to scale.