Table 2.
Reported formation of CAMS (or not), depending on the preparation method for the top five drugs used for CAMS: indomethacin, mebendazole, carvedilol, carbamazepine, and simvastatin. For carbamazepine, only CAMS upon ball milling were reported and are not included in this table. Y: Yes, N: No. LAG: Liquid-assisted grinding.
| Drug | Amino Acid | Co- Amorphous (Y/N) |
Preparation Method | Notes | Reference |
|---|---|---|---|---|---|
| Carvedilol | Aspartic acid | N | Ball milling | [29,41,54,103] | |
| Carvedilol | Aspartic acid | Y | Spray drying | Dependent on solvent composition | [72,103,104] |
| Carvedilol | Aspartic acid | N | LAG | [103] | |
| Carvedilol | Glutamic acid | N | Ball milling | [29,41,54,103] | |
| Carvedilol | Glutamic acid | Y | Spray drying | Dependent on solvent composition | [72,103] |
| Carvedilol | Glutamic acid | N | LAG | [103] | |
| Indomethacin | Histidine | N | Ball milling | [29,41,54,103] | |
| Indomethacin | Histidine | Y | Spray drying | [105,106] | |
| Indomethacin | Lysine | Y | Ball milling | 60 min | [29,41,54,107,108] |
| Indomethacin | Lysine | N | Ball milling | 60 min at 4 °C | [105] |
| Indomethacin | Lysine | Y | Spray drying | [105,106,107] | |
| Indomethacin | Lysine | N | LAG | Crystalline salt was formed | [108] |
| Mebendazole | Phenylalanine | Y | Ball milling | 60 min | [29,41,54,107] |
| Mebendazole | Phenylalanine | N | Ball milling | Up to 180 min at 4 °C | [109,110] |
| Mebendazole | Proline | Y | Ball milling | Up to 180 min at 4 °C | [110] |
| Mebendazole | Proline | N | Ball milling | 60 min | [29,41,54] |
| Simvastatin | Tryptophan | Y | Ball milling | [29,41,54] | |
| Simvastatin | Tryptophan | N | Spray drying | [111] |