Table 5.

CAMS reported between a basic drug and a basic amino acid as a co-former, as well as no formation of CAMS reported between an acidic drug and a basic amino acid as a co-former. LAG: Liquid-assisted grinding. * CAMS between glimepiride and arginine was formed using the supercritical antisolvent technique with supercritical carbon dioxide.

Drug	Amino Acid	Co- Amorphous (Y/N)	Preparation Method	Molar Ratio	Reference
Ibrutinib	Arginine	N	LAG	1:1	[36]
Cimetidine	Arginine	Y	Ball milling	1:1	[117]
Glimepiride	Arginine	N	Ball milling, Melt-quench, Solvent evaporation	1:1	[87] *
Mebendazole	Arginine	Y, but two-phase system	Ball milling	1:1	[117]
Ibrutinib	Histidine	N	LAG	1:2	[36]
Indomethacin	Histidine	N	Ball milling	1:1	[103]
Glibenclamide	Lysine	N	Cryo-milling	1:1	[28]
Indomethacin	Lysine	N	Ball milling	1:1	[103]